BASIC SCIENCE JOURNAL CLUB OF EUSTAR YIG
Dysregulations in the oxidant/antioxidant balance are known to be
major factors in the pathogenesis of systemic sclerosis (SSc).
NRF2 acts as a key player in the antioxidant defense by
controlling the transcription of antioxidant and cytoprotective
genes. In this article, the authors explored the involvement of a
down-expression of NRF2 in the pathogenesis of SSc and the
relevance of a NRF2 agonist, as a potent therapeutic option in SSc.READ MORE