Project Description

BASIC SCIENCE JOURNAL CLUB OF EUSTAR YIG
Sep-Dec 2018

Dysregulations in the oxidant/antioxidant balance are known to be major factors in the pathogenesis of systemic sclerosis (SSc). NRF2 acts as a key player in the antioxidant defense by controlling the transcription of antioxidant and cytoprotective genes. In this article, the authors explored the involvement of a down-expression of NRF2 in the pathogenesis of SSc and the relevance of a NRF2 agonist, as a potent therapeutic option in SSc.
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