BASIC SCIENCE JOURNAL CLUB OF EUSTAR YIG MAY AGU 2018

BASIC SCIENCE JOURNAL CLUB OF EUSTAR YIG MAY AGU 20182018-10-07T09:03:55+00:00

Project Description

BASIC SCIENCE JOURNAL CLUB OF EUSTAR YIG
May-Agu 2018

The enzyme poly(ADP-ribose) polymerase-1 also called PARP-1, is a member of the PARP family, a group of 18 enzymes that transfer ADP-ribose groups onto various substrate proteins. This mechanism called PARylation, exerts profound regulatory effects on many physiological and pathological processes. Among PARPs, PARP-1 is by far the most well characterized and it has been recently shown that PARP-1 could PARylate Smad proteins. As Smad proteins take part in TGFβ signaling, a key pathway involved in the pathogenesis of fibrosis is systemic sclerosis (SSc), modulation of PARP-1 and PARylation may also have regulatory effects on fibrosis. In this article, the authors have explored the links between PARP-1 and TGFβ signaling and the impact of a modulation of PARP-1-dependent PARylation on fibrosis both in vitro and in vivo.
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